Traducción por control remoto

Pascal Preker1, Torben Heick Jensen

  • 1Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, C.F. Møllers Allé 3, Building 1130, Aarhus University, 8000 Aarhus, Denmark. pap@mb.au.dk

Cell
|November 16, 2010
PubMed
Resumen

Las subunidades de la ARN polimerasa II Rbp4p y Rpb7p imprimen los ARN mensajeros (ARNm) durante la transcripción. Este proceso de impresión guía las transcripciones de ARNm a la maquinaria de traducción para la síntesis de proteínas.

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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