Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Electrochemical Systems01:24

Electrochemical Systems

Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution, the Zn metal, composed...
Electrochemical Gradient and Channel Proteins: An Overview01:21

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell.  This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Channel Rhodopsins01:11

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
The Electrical Double Layer01:30

The Electrical Double Layer

In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Erratum: "Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models" [J. Chem. Phys. 161, 094113 (2024)].

The Journal of chemical physics·2026
Same author

From Intermolecular Poses to Thermodynamics Using Subdivided Spheres.

The journal of physical chemistry. B·2026
Same author

HemoDens: A global hemostasis analyzer for kinetic characterization of clot formation, retraction, and lysis.

Thrombosis research·2025
Same author

Evaluation of MRX PT DOAC as a new screening method for detecting interferences in thrombophilia analyses.

Scandinavian journal of clinical and laboratory investigation·2025
Same author

Enhanced diffusion through multivalency.

Soft matter·2024
Same author

Strong electrostatic attraction drives milk heteroprotein complex coacervation.

International journal of biological macromolecules·2024
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 6, 2026

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
10:35

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli

Published on: August 13, 2016

Camaleones electrostáticos en sistemas biológicos.

Mikael Lund1

  • 1Department of Theoretical Chemistry, Lund University, POB 124, SE-22100 Lund, Sweden. mikael.lund@teokem.lu.se

Journal of the American Chemical Society
|November 20, 2010
PubMed
Resumen
Este resumen es generado por máquina.

Los iones cargados como el ortofosfato y la histidina actúan como interruptores de proximidad electrostáticos, regulando su carga cerca de las interfaces. Este mecanismo de regulación de carga es crucial para los procesos biológicos y técnicos.

Más Videos Relacionados

Observation of Photobehavior in Chlamydomonas reinhardtii
03:54

Observation of Photobehavior in Chlamydomonas reinhardtii

Published on: May 6, 2022

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
08:39

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins

Published on: May 22, 2017

Videos de Experimentos Relacionados

Last Updated: Jun 6, 2026

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
10:35

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli

Published on: August 13, 2016

Observation of Photobehavior in Chlamydomonas reinhardtii
03:54

Observation of Photobehavior in Chlamydomonas reinhardtii

Published on: May 6, 2022

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
08:39

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins

Published on: May 22, 2017

Área de la Ciencia:

  • La biofísica es la biofísica.
  • Química Física es la química física.
  • Biología computacional Biología computacional.

Sus antecedentes:

  • Los protones exhiben importantes fluctuaciones de equilibrio en el pH fisiológico.
  • La carga de iones como el grupo imidazol del ortofosfato y la histidina es sensible a su entorno.
  • Las interacciones con las interfaces cargadas son fundamentales en los sistemas biológicos.

Objetivo del estudio:

  • Para cuantificar el mecanismo de regulación de carga de los iones cerca de las interfaces cargadas.
  • Investigar el papel de los iones como interruptores de proximidad electrostáticos.
  • Para explorar la relevancia biológica y técnica de este reglamento de cargas.

Principales métodos:

  • Termodinámica estadística para la cuantificación teórica.
  • Simulaciones computarizadas mesoscópicas para modelar las interacciones.
  • Análisis del comportamiento iónico cerca de las interfaces del modelo (por ejemplo, membranas lipídicas, ADN).

Principales resultados:

  • Los iones como el ortofosfato y la histidina regulan dinámicamente su carga en función de la proximidad a las interfaces cargadas.
  • Esta regulación de carga funciona como un interruptor de proximidad electrostático, modulando la intensidad de la interacción.
  • El mecanismo demostró ser significativo en varios contextos biológicos y técnicos.

Conclusiones:

  • La regulación de la carga por los iones es un mecanismo clave que rige las interacciones con las interfaces biológicas y artificiales.
  • Este fenómeno tiene amplias implicaciones para la comprensión del reconocimiento molecular, los procesos celulares y el diseño de nuevos materiales.
  • El modelo de interruptor de proximidad electrostático proporciona un marco para estudiar estas interacciones.