Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Dry Friction01:30

Dry Friction

Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
Rolling With Slipping01:14

Rolling With Slipping

Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
Shearing Stress01:18

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Wood Surfacing01:14

Wood Surfacing

Wood surfacing is a critical finishing process designed to smoothen the wood surface, enhance its dimensional accuracy, and make handling safer. This process compensates for potential shrinkage during the seasoning phase by marginally increasing the wood dimensions before surfacing. It also helps correct some distortions that may occur as the wood dries.
The equipment used in the surfacing process is a plane equipped with rotating blades. This tool efficiently smoothens the wood surface and can...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

The secretory pathway gets a molecular framework.

Nature reviews. Molecular cell biology·2025
Same author

The Erv41-Erv46 complex serves as a retrograde receptor to retrieve misfolded secretory proteins that have escaped from the ER.

Molecular biology of the cell·2025
Same author

The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery.

Journal of cell science·2023
Same author

Twenty-five years after coat protein complex II.

Molecular biology of the cell·2019
Same author

Molecular dissection of the Erv41-Erv46 retrograde receptor reveals a conserved cysteine-rich region in Erv46 required for retrieval activity.

Molecular biology of the cell·2019
Same author

Conserved juxtamembrane domains in the yeast golgin Coy1 drive assembly of a megadalton-sized complex and mediate binding to tethering and SNARE proteins.

The Journal of biological chemistry·2019

Video Experimental Relacionado

Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Las hojas de emergencias se endurecen.

Charles Barlowe1

  • 1Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. charles.barlowe@dartmouth.edu

Cell
|November 30, 2010
PubMed
Resumen

Las proteínas que forman las estructuras de chapa del retículo endoplasmático (ER) se enriquecen por asociación con los ribosomas. Las proteínas que inducen la curvatura se encuentran en los bordes de las láminas de la membrana ER.

Área de la Ciencia:

  • Biología celular Biología celular.
  • Biología Molecular Biología Molecular
  • La bioquímica es la bioquímica.

Sus antecedentes:

  • La membrana del retículo endoplasmático (ER) forma complejas estructuras tubulares y de láminas.
  • Los mecanismos moleculares que gobiernan la organización de la membrana ER no se comprenden completamente.

Objetivo del estudio:

  • Para investigar las proteínas responsables de dar forma a la membrana ER en hojas y tubos.
  • Comprender la localización y la función de las proteínas que inducen la hoja y la curvatura dentro de la ER.

Principales métodos:

  • Microscopía de inmunofluorescencia para visualizar la localización de proteínas.
  • Ensayos bioquímicos para estudiar las interacciones proteína-proteína.
  • Fraccionamiento celular para aislar diferentes dominios de la membrana ER.

Más Videos Relacionados

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials
10:18

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials

Published on: January 5, 2019

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
08:32

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

Published on: June 30, 2019

Videos de Experimentos Relacionados

Last Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials
10:18

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials

Published on: January 5, 2019

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
08:32

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

Published on: June 30, 2019

Principales resultados:

  • Las proteínas inductoras de hojas, como Climp-63, se concentran en la ER áspera debido a la unión con los ribosomas unidos a la membrana.
  • Las proteínas que inducen la curvatura están específicamente localizadas en los bordes altamente curvados de las láminas de membrana ER.
  • Esta localización diferencial sugiere un mecanismo coordinado para la morfogénesis de la membrana ER.

Conclusiones:

  • La asociación de ribosomas es un factor clave en la concentración de proteínas formadoras de hojas en el ER áspero.
  • Diferentes poblaciones de proteínas regulan la formación de las láminas de ER y sus bordes curvos.
  • Estos hallazgos proporcionan nuevos conocimientos sobre la maquinaria molecular que impulsa la formación de la estructura ER.