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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Ácido zoledrónico en el mieloma: MRC Mieloma IX

Name: Inhibition of Osteoclastogenesis by LY90009 through Notch Signaling Modulation in Osteolytic Disease Models
Uploaded: 2025-10-07T13:20:00.000Z
Duration: 1 min
Description: Here, we present a protocol to evaluate the inhibitory effects of the γ-secretase inhibitor LY900009 on RANKL-induced osteoclastogenesis in bone marrow-derived macrophages. The protocol includes cytotoxicity assessment, functional assays, molecular analyses, and in vivo validation in a murine osteolytic model, with applications in the therapeutic development of osteolytic diseases.

S Vincent Rajkumar¹

¹Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA. rajkumar.vincent@mayo.edu

Lancet (London, England)

|December 7, 2010

Resumen

No abstract available in PubMed .

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