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Determinación del sexo en la ameba social Dictyostelium discoideum
Gareth Bloomfield1, Jason Skelton, Alasdair Ivens
1Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. garethb@mrc-lmb.cam.ac.uk
Science (New York, N.Y.)
|December 15, 2010
Resumen
Los investigadores descubrieron el locus de tipo de apareamiento en Dictyostelium discoideum, revelando nuevos genes para la determinación del sexo. Este hallazgo arroja luz sobre la genética de los tipos de apareamiento en este organismo modelo.
Área de la Ciencia:
- Genética La genética.
- Biología Molecular Biología Molecular
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- La genética de la determinación del sexo es poco conocida en muchas especies.
- Dictyostelium discoideum es un organismo modelo con tres tipos de apareamiento.
Objetivo del estudio:
- Para identificar y analizar el locus de tipo de apareamiento en Dictyostelium discoideum.
- Comprender la base genética de la determinación del sexo en este organismo.
Principales métodos:
- Análisis genético del locus de tipo de apareamiento.
- Análisis de secuencia de genes involucrados en la determinación del tipo de apareamiento.
Principales resultados:
- Tres formas de un solo locus determinan los tres tipos de apareamiento.
- Dos tipos de apareamiento están controlados por genes únicos y no relacionados.
- El tercer tipo de apareamiento requiere homólogos de ambos genes.
- Los genes clave codifican nuevos polipéptidos no relacionados con las familias de proteínas conocidas.
Conclusiones:
- La determinación del sexo en Dictyostelium discoideum utiliza reguladores genéticos únicos.
- Este descubrimiento proporciona nuevos conocimientos sobre la evolución de los mecanismos de determinación del sexo.
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