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Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules
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Published on: April 25, 2025

La total flexibilidad de las proteínas es esencial para el correcto mapeo de puntos calientes.

Katrina W Lexa1, Heather A Carlson

  • 1Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1065, United States.

Journal of the American Chemical Society
|December 17, 2010
PubMed
Resumen

El mapeo preciso de puntos calientes para el diseño de fármacos basado en la estructura requiere tener en cuenta la flexibilidad de las proteínas. Las simulaciones revelan que solo las proteínas totalmente flexibles, no las rígidas, identifican correctamente los sitios de unión eliminando mínimos espurios.

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