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CRTC3 vincula la señalización de catecolaminas con el balance energético
Youngsup Song1, Judith Altarejos, Mark O Goodarzi
1The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nature
|December 18, 2010
Resumen
El coactivador Crtc3 promueve la obesidad al debilitar los efectos de los receptores beta-adrenérgicos en las células grasas. Una variante común de CRTC3 está relacionada con la obesidad en poblaciones humanas.
Área de la Ciencia:
- Regulación del metabolismo.
- Biología del tejido adiposo Biología del tejido adiposo
- Investigación de la obesidad.
Sus antecedentes:
- La leptina regula el equilibrio energético a través de la activación del sistema nervioso simpático.
- La señalización de los receptores beta-adrenérgicos en los adipocitos impulsa el gasto de energía a través de la lipólisis y la oxidación de los ácidos grasos.
- La interrupción de la señalización de catecolaminas está implicada en la obesidad y la resistencia a la insulina.
Objetivo del estudio:
- Para investigar el papel del coactivador CREB Crtc3 en la obesidad.
- Para aclarar el mecanismo por el cual Crtc3 influye en la señalización del receptor beta-adrenérgico en el tejido adiposo.
Principales métodos:
- Investigó la activación de Crtc3 en respuesta a las señales de catecolaminas.
- Se evaluó el efecto de Crtc3 en la actividad de la adenil ciclasa y la expresión de Rgs2.
- Examinó la asociación de una variante humana del CRTC3 con la adiposidad en cohortes mexicano-americanas.
Principales resultados:
- Se encontró que Crtc3 atenúa la señalización del receptor beta-adrenérgico en el tejido adiposo.
- La activación de Crtc3 redujo la actividad de la adenil ciclasa al regular al alza la expresión de Rgs2.
- Una variante común del CRTC3 humano con mayor actividad transcripcional correlacionada con adiposidad.
Conclusiones:
- El adipocito Crtc3 juega un papel en la promoción de la obesidad.
- Crtc3 puede contribuir al desarrollo de la obesidad en humanos a través de sus efectos en la señalización de las células grasas.
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