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Representaciones corticales de la entrada olfativa por el rastreo trans-sináptico.
Kazunari Miyamichi1, Fernando Amat, Farshid Moussavi
1HHMI/Department of Biology, Stanford University, Stanford, California 94305, USA.
Nature
|December 24, 2010
Resumen
Los investigadores mapearon las vías olfativas en ratones, revelando cómo el mapa de olor del bulbo olfativo se procesa en la corteza. Las neuronas corticales individuales integran señales de glomérulos del bulbo olfativo ampliamente distribuidos, con diferentes áreas corticales que muestran patrones de entrada distintos.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación del sistema olfativo Investigación del sistema olfativo.
- Connectomics es una empresa de conectividad.
Sus antecedentes:
- El bulbo olfativo del ratón crea un mapa del olor a través de proyecciones axonales convergentes de las neuronas receptoras olfativas a glomérulos específicos.
- La representación de este mapa de olor del bulbo olfativo dentro de la corteza olfativa sigue siendo en gran medida no caracterizada.
Objetivo del estudio:
- Para investigar cómo el mapa del olor del bulbo olfativo está representado en la corteza olfativa.
- Para dilucidar la conectividad presináptica de las neuronas corticales que reciben información olfativa.
Principales métodos:
- Utilizó el etiquetado mono-trans-sináptico retrógrado dependiente del virus de la rabia.
- Empleó técnicas genéticas para controlar las neuronas corticales "de arranque" para rastrear las entradas presinápticas.
Principales resultados:
- Las neuronas corticales individuales reciben una entrada convergente de múltiples células mitrales, que representan glomérulos ampliamente distribuidos.
- Representación diferencial demostrada de la entrada del bulbo olfativo a través de áreas corticales, con la amígdala cortical que favorece la entrada dorsal y el muestreo de la corteza piriforme en general.
Conclusiones:
- Las distintas áreas corticales olfativas procesan la información del bulbo olfativo de manera diferente, lo que probablemente refleja funciones especializadas en la preferencia y la memoria del olor.
- La técnica de etiquetado trans-sináptico desarrollada ofrece una herramienta versátil para mapear las conexiones neuronales a través del sistema nervioso del ratón.
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