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Señalización Wnt: los cuerpos multivesiculares mantienen cautivos a GSK3
Christof Niehrs1, Sergio P Acebron
1German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany. niehrs@dkfz.de
Cell
|December 25, 2010
Resumen
La señalización Wnt inactiva la Glycogen Synthase Kinase 3 (GSK3) al atraparla dentro de los compartimentos celulares llamados cuerpos multivesiculares. Este descubrimiento vincula la inactivación de GSK3 a la endocitosis del receptor, ofreciendo un nuevo modelo para la regulación de la vía Wnt.
Área de la Ciencia:
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
- La bioquímica es la bioquímica.
Sus antecedentes:
- La transducción de la señal Wnt es crucial para el desarrollo embrionario y la homeostasis del tejido adulto.
- Los eventos clave, incluida la endocitosis del receptor y la inactivación de la Glycogen Synthase Kinase 3 (GSK3), son fundamentales para la señalización de Wnt.
- Los mecanismos precisos que vinculan estos eventos han permanecido poco claros, lo que dificulta una comprensión completa de la trayectoria.
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