Video Experimental Relacionado
Updated: Jun 5, 2026
10:26
Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
¿Son los cuerpos del grupo de policombos fábricas de silenciamiento genético?
Jacob W Hodgson1, Hugh W Brock
1Department of Zoology, University of British Columbia, Vancouver BC, Canada.
Cell
|January 19, 2011
Resumen
Las proteínas del grupo policombino (PcG) ayudan a silenciar los genes Hox al asociarlos a largas distancias. Este estudio muestra que la ubicación de los genes Hox en el núcleo es clave para el silenciamiento genético mediado por PcG.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Genética La genética.
- La epigenética es la epigenética.
Sus antecedentes:
- Las proteínas del grupo de policombos (PcG) son reguladores epigenéticos conocidos por reprimir la expresión génica.
- Los genes Hox son cruciales para el desarrollo y a menudo son objetivos de la represión mediada por PcG.
- Las interacciones de cromatina de largo alcance están implicadas en la regulación génica.
Videos de Conceptos Relacionados
02:33Combinatorial Gene Control
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
02:04Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...