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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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La α-fluorización organocatalítica enantioselectiva de las cetonas cíclicas

Piotr Kwiatkowski1, Teresa D Beeson, Jay C Conrad

  • 1Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.

Journal of the American Chemical Society
|January 21, 2011
PubMed
Resumen

Los investigadores lograron la primera alfa-fluorización altamente enantioselectiva de cetonas mediante el uso de organocatálisis. Este avance supera un desafío de larga data, permitiendo la fluoración asimétrica de diversos sustratos con un excelente control.

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