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Los ritmos circadianos persisten sin transcripción en un eucariota
John S O'Neill1, Gerben van Ooijen, Laura E Dixon
1Centre for Systems Biology at Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK.
Nature
|January 29, 2011
Resumen
Los ritmos diarios en los eucariotas no están impulsados únicamente por la expresión génica. Los mecanismos no transcripcionales, como la oxidación de peroxiredoxina, son suficientes para el cronometraje circadiano y se conservan en todas las especies.
Área de la Ciencia:
- * Cronobiología y biología molecular.
- * Sistemas circadianos de las eucariotas.
Sus antecedentes:
- * Los ritmos circadianos regulan los procesos biológicos diarios en los eucariotas, impulsados por circuitos de retroalimentación transcripcional-traducional.
- * Si bien los componentes del reloj transcripcional varían según los reinos, los mecanismos post-transcripcionales son cada vez más reconocidos.
- * La alga unicelular *Ostreococcus tauri* tiene un reloj simplificado con características similares a las de las plantas.
Objetivo del estudio:
- * Investigar la suficiencia y conservación de los mecanismos no transcripcionales en el cronometraje circadiano de los eucariotas.
- * Reevaluar el papel de los componentes transcripcionales en la función del oscilador a la luz de los hallazgos posteriores a la traducción.
Principales métodos:
- * Análisis de los ritmos circadianos en *Ostreococcus tauri*.
- * Identificación de biomarcadores rítmicos independientes de la transcripción.
- * Modulación farmacológica de los mecanismos de reloj de los mamíferos y evaluación de los efectos sobre los ritmos de *Ostreococcus*.
Principales resultados:
- * Los mecanismos no transcripcionales son suficientes para mantener el cronometraje circadiano en eucariotas, a menudo trabajando junto con elementos transcripcionales.
- * Oxidación de proteínas de peroxiredoxina identificadas como un biomarcador rítmico independiente de la transcripción, también observado en mamíferos.
- * Los agentes farmacológicos que afectan a los ritmos circadianos de los mamíferos impactan en el *Ostreococcus*.
Conclusiones:
- * Los mecanismos post-traduccionales y los marcadores rítmicos específicos (por ejemplo, la oxidación de la peroxiredoxina) están más conservados en los reinos eucariotas que los reguladores del reloj transcripcional.
- * Sugiere que los componentes de los antiguos osciladores circadianos pueden ser no transcripcionales, similares a las cianobacterias, y conservados a lo largo de la evolución.
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