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9p21 Las variantes de ADN asociadas con la enfermedad de las arterias coronarias afectan la respuesta de señalización

Olivier Harismendy1, Dimple Notani, Xiaoyuan Song

  • 1Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA.

Nature
|February 11, 2011
PubMed
Resumen

Las variantes genéticas en la región 9p21 están relacionadas con la enfermedad de las arterias coronarias (CAD) y la diabetes tipo 2. Este estudio identifica potenciadores en 9p21, revelando cómo los alelos de riesgo interrumpen la unión STAT1 e influyen en la expresión génica en respuesta a la inflamación.

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