Video Experimental Relacionado
Updated: Jun 4, 2026
29:13
Microbial Communities in Nature and Laboratory - Interview
Published on: May 28, 2007
Sobre el futuro de los datos genómicos.
1Illumina, 9885 Towne Centre Drive, San Diego, CA 92121, USA.
Science (New York, N.Y.)
|February 12, 2011
Resumen
La investigación genómica se enfrenta a desafíos informáticos debido a los datos masivos de secuenciación. Abordar el almacenamiento de datos, la seguridad y la privacidad es crucial para el avance de la genómica.
Área de la Ciencia:
- La genómica es la genómica.
- La bioinformática es la bioinformática.
- Biología computacional Biología computacional.
Sus antecedentes:
- Las tecnologías de secuenciación altamente multiplexadas generan grandes cantidades de datos genómicos crudos.
- La escala de datos producidos por las actuales operaciones de secuenciación requiere una importante infraestructura informática.
Objetivo del estudio:
- Para resaltar los desafíos informáticos asociados con los datos genómicos a gran escala.
- Subrayar la importancia de la gestión de datos, la seguridad y la privacidad en la investigación genómica.
Principales métodos:
- Análisis de la generación de datos de secuenciación de alto rendimiento.
- Revisión de las necesidades actuales de informática en genómica.
Principales resultados:
- Las ejecuciones de secuenciación ahora producen terabytes de datos, lo que requiere capacidades robustas de almacenamiento y análisis.
- El creciente volumen de datos genómicos presenta importantes obstáculos informáticos para los laboratorios de investigación.
Conclusiones:
- Las soluciones informáticas efectivas son esenciales para la gestión y el análisis de grandes conjuntos de datos genómicos.
- Asegurar el acceso a la información, la seguridad de los datos y la privacidad del paciente es fundamental para el progreso continuo de la genómica.
Más Videos Relacionados
Videos de Conceptos Relacionados
03:00Next-generation Sequencing
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
01:57Sanger Sequencing
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
00:58Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
01:05Maxam-Gilbert Sequencing
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
Challenges of the Maxam-Gilbert Method
The...
03:36Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.