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El virus de ARN de Leishmania controla la gravedad de la leishmaniasis mucocutánea
Annette Ives1, Catherine Ronet, Florence Prevel
1Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Science (New York, N.Y.)
|February 12, 2011
Resumen
El virus de ARN-1 de Leishmania (LRV1) en los parásitos de Leishmania desencadena respuestas inmunes del huésped que paradójicamente empeoran la leishmaniasis mucocutánea. Este ARN viral subvierte la inmunidad, promoviendo la persistencia del parásito y la progresión de la enfermedad.
Área de la Ciencia:
- Inmunología Inmunología.
- Parasitología Parasitología.
- Virología Virología.
Sus antecedentes:
- La leishmaniasis mucocutánea, causada por los parásitos Leishmania Viannia, conduce a lesiones nasofaríngeas destructivas.
- Los mecanismos precisos que impulsan el desarrollo de la lesión siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para investigar el papel de Leishmania RNA virus-1 (LRV1) en la patogénesis de la leishmaniasis mucocutánea.
Principales métodos:
- Análisis de la carga de parásitos en la metástasis de Leishmania guyanensis.
- Investigando el reconocimiento del receptor Toll-like receptor 3 (TLR3) del huésped de LRV1.1.
- Evaluación de las respuestas inmunes y la gravedad de la enfermedad en ratones infectados.
Principales resultados:
- Los parásitos metastásicos exhibieron una carga alta de Leishmania RNA virus-1 (LRV1).
- El huésped TLR3 reconoció LRV1, induciendo citocinas y quimiocinas proinflamatorias.
- La activación de TLR3 aumentó inesperadamente la susceptibilidad a las infecciones, lo que condujo a una mayor hinchazón y parasitemia en ratones.
Conclusiones:
- LRV1 dentro de los parásitos de Leishmania subvierte las respuestas inmunes del huésped.
- Esta subversión inmune promueve la persistencia de los parásitos y exacerba la patología de la leishmaniasis mucocutánea.
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