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Marcas distintivas del cáncer: la próxima generación
Douglas Hanahan1, Robert A Weinberg
1The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne CH-1015, Switzerland. dh@epfl.ch
Cell
|March 8, 2011
Resumen
El cáncer se desarrolla a través de seis capacidades biológicas clave, conocidas como las señas de identidad del cáncer. Comprender estas características y el microambiente tumoral es crucial para desarrollar nuevos tratamientos contra el cáncer.
Área de la Ciencia:
- Oncología Oncología.
- Biología del cáncer Biología del cáncer.
Sus antecedentes:
- Las características del cáncer proporcionan un marco para la comprensión de la enfermedad neoplásica.
- Estas señas de identidad son capacidades biológicas adquiridas durante el desarrollo del tumor.
Objetivo del estudio:
- Para esbozar las características establecidas y emergentes del cáncer.
- Para discutir el papel de la inestabilidad del genoma, la inflamación y el microambiente tumoral.
Principales métodos:
- Revisión conceptual y síntesis de las características de cáncer establecidas.
- La inclusión de las características emergentes: reprogramación metabólica y evasión inmune.
- La consideración de la contribución del microambiente del tumor.
Principales resultados:
- Seis características principales: proliferación sostenida, evasión de la supresión del crecimiento, resistencia a la muerte celular, inmortalidad replicativa, angiogénesis y invasión / metástasis.
- La inestabilidad del genoma y la inflamación son factores subyacentes.
- Las características emergentes incluyen la reprogramación metabólica y la evasión inmune.
- El microambiente tumoral comprende las células reclutadas que influyen en la adquisición de la marca.
Conclusiones:
- Las características del cáncer ofrecen un principio organizativo para la investigación del cáncer.
- Comprender estas características y el microambiente tumoral es vital para el avance de la terapia contra el cáncer.
- Este marco conceptual guiará el desarrollo de nuevos tratamientos contra el cáncer.
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