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CRYPTOCHROME es un sensor de luz azul que regula la velocidad de disparo de las neuronas
Keri J Fogle1, Kelly G Parson, Nicole A Dahm
1Department of Physiology and Biophysics, University of California-Irvine, Irvine, CA 92697, USA.
Science (New York, N.Y.)
|March 10, 2011
Resumen
Las moscas de la fruta poseen un nuevo mecanismo de detección de luz en las neuronas del cerebro. Esta vía, mediada por CRYPTOCHROME (CRY), permite a las neuronas responder directamente a la luz sin los fotorreceptores tradicionales.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Cronobiología cronobiología.
Sus antecedentes:
- Las respuestas neurales a la luz generalmente dependen de las proteínas de la opsina y los fotorreceptores externos.
- La sensibilidad a la luz directa de las neuronas del cerebro central se entiende menos, especialmente sin opsinas.
Objetivo del estudio:
- Para investigar una respuesta a la luz no mediada por opsina en Drosophila melanogaster.
- Identificar los mecanismos moleculares y los componentes celulares involucrados en esta sensibilidad neuronal directa a la luz.
Principales métodos:
- Se utilizaron modelos de Drosophila melanogaster con manipulaciones genéticas.
- Actividad neuronal medida y cambios en el potencial de membrana en respuesta a estímulos de luz.
- Investigó el papel del criptocromo (CRY) y los canales de potasio.
Principales resultados:
- Las grandes neuronas de excitación ventral lateral (lLNvs) exhiben potenciales de acción evocados por la luz en cuestión de segundos.
- Esta respuesta es selectiva de longitud de onda para la luz azul, coincidiendo con la sensibilidad de CRYPTOCHROME (CRY).
- La expresión de CRYPTOCHROME (CRY) en lLNvs es necesaria y suficiente para la respuesta a la luz, independiente de las opsins.
- El mecanismo involucra la redox de la flavina y la conductancia del canal de potasio, distintas de las interacciones circadianas CRY-TIMELESS.
Conclusiones:
- Las neuronas centrales de Drosophila pueden percibir la luz directamente a través de CRYPTOCHROME (CRY).
- Esta vía dependiente del criptocromo (CRY) ofrece un nuevo mecanismo para la detección de luz neuronal.
- Los hallazgos amplían nuestra comprensión de la percepción de la luz no visual en el cerebro.
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