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Videos de Conceptos Relacionados

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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Increased fracture risk associated with iron-deficiency anemia: a population-based propensity score matched cohort study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
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<i>Thra</i> knockout protects male mice from hyperthyroidism-driven cortical bone loss by mitigating bone resorption.

JBMR plus·2026
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Deconstructing senescence phenotypes in cells of the bone and bone marrow.

The Journal of clinical investigation·2026
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Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2026
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Palopegteriparatide for Adults with Chronic Hypoparathyroidism: Skeletal Dynamics Through 3 yr of the Phase 2 paTH Forward Trial.

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Video Experimental Relacionado

Updated: Jun 3, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Osteoporosis: ahora y el futuro.

Tilman D Rachner1, Sundeep Khosla, Lorenz C Hofbauer

  • 1Division of Endocrinology, Diabetes, and Bone Diseases, Dresden Technical University Medical Centre, Dresden, Germany.

Lancet (London, England)
|April 1, 2011
PubMed
Resumen

El tratamiento de la osteoporosis está avanzando con nuevas terapias dirigidas a la reabsorción y formación ósea. Los nuevos medicamentos como el denosumab, el odanacatib y los anticuerpos contra la esclerostina/dickkopf-1 ofrecen estrategias prometedoras para controlar la fragilidad ósea.

Videos de Experimentos Relacionados

Last Updated: Jun 3, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Área de la Ciencia:

  • Biología ósea y vías de señalización molecular.
  • La osteoporosis y su impacto en la salud ósea.

Sus antecedentes:

  • La osteoporosis causa deterioro óseo sistémico, lo que lleva a fracturas, con una prevalencia creciente en las poblaciones de envejecimiento.
  • La comprensión de la comunicación entre osteoblastos y osteoclastos es clave para identificar nuevos objetivos terapéuticos.

Objetivo del estudio:

  • Revisar nuevas estrategias terapéuticas para la osteoporosis.
  • Para discutir la fisiología subyacente de los tratamientos emergentes de la osteoporosis.

Principales métodos:

  • Revisión de la literatura científica actual sobre la osteoporosis y nuevos tratamientos.
  • Análisis de conocimientos moleculares sobre las redes de comunicación y señalización de las células óseas.

Principales resultados:

  • Identificación de nuevos objetivos terapéuticos mediante la comprensión de la biología ósea.
  • Desarrollo de tratamientos para inhibir la resorción ósea y mejorar la formación ósea.

Conclusiones:

  • Las nuevas terapias que incluyen denosumab, odanacatib y anticuerpos contra la esclerostina/dickkopf-1 son prometedoras.
  • Estos tratamientos se dirigen a vías clave en la actividad de los osteoclastos y osteoblastos para el manejo de la osteoporosis.