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Phase Transitions and Effect of Intermolecular Forces

Phase Transitions and Effect of Intermolecular Forces

Cambios en la adhesión de los queratinocitos durante la diferenciación terminal: la reducción de la unión a la

J C Adams¹, F M Watt

¹Keratinocyte Laboratory, Imperial Cancer Research Fund, London, England.

|October 19, 1990

Resumen

Durante la diferenciación terminal de los queratinocitos, las células pierden la adhesión a la membrana basal. Esto implica cambios en la función de la integrina, impactando la migración celular desde la capa basal de la epidermis.

Área de la Ciencia:

Biología celular Biología celular.
Dermatología Dermatología dermatología.
Integración de la señalización integrin.

Sus antecedentes:

Los queratinocitos en la epidermis basal se adhieren a la membrana basal.
La diferenciación terminal implica la migración de los queratinocitos fuera de la capa basal.
Los mecanismos moleculares de esta migración no se comprenden completamente.

Objetivo del estudio:

Para investigar los cambios en la adhesión de los queratinocitos durante la diferenciación terminal.
Determinar el papel de las integrinas en la adhesión y migración de los queratinocitos.

Principales métodos:

Los queratinocitos humanos cultivados fueron inducidos a someterse a la diferenciación terminal.
Se realizaron ensayos de adhesión celular utilizando fibronectina, laminina y colágeno de los tipos I y IV.
La expresión y función de la integrina de la superficie celular se analizaron utilizando citometría de flujo y ensayos de adhesión.

Principales resultados:

La diferenciación terminal condujo a una disminución de la adhesión de los queratinocitos a la fibronectina, la laminina y el colágeno.
Los cambios adhesivos precedieron a la pérdida de las integrinas alfa 2 beta 1, alfa 3 beta 1 y alfa 5 beta 1.
La adhesión de los queratinocitos a la fibronectina fue mediada por la integrina alfa 5 beta 1, y su función de unión disminuyó durante la diferenciación.

Conclusiones:

La modulación de la función de la integrina es un evento temprano en la diferenciación terminal de los queratinocitos.
Las interacciones integrina-matriz alteradas pueden regular la migración de los queratinocitos fuera de la capa basal.
Estos hallazgos proporcionan información sobre la regulación de la homeostasis epidérmica y la cicatrización de heridas.

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