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OMP descarboxilasa: la energía de unión del fosfodianión se utiliza para estabilizar un intermediario del carbanión

Bogdana Goryanova1, Tina L Amyes, John A Gerlt

  • 1Department of Chemistry, University at Buffalo, Buffalo, New York 14260, USA.

Journal of the American Chemical Society
|April 14, 2011
PubMed
Resumen

La orotidina 5'-monofosfato descarboxilasa (OMPDC) facilita el intercambio de deuterio en un análogo del fluorouracilo. El fosfito dianio estabiliza significativamente el estado de transición, revelando su papel en las reacciones enzimáticas.

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