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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
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Vertido genital del virus del herpes simplex entre personas sintomáticas y asintomáticas con infección por HSV-2
Elizabeth Tronstein1, Christine Johnston, Meei-Li Huang
1Department of Medicine, University of Washington, Seattle, USA.
JAMA
|April 14, 2011
Resumen
Las personas con síntomas del virus del herpes genital simple tipo 2 (HSV-2) arrojan el virus con más frecuencia que las personas con infecciones asintomáticas. Sin embargo, la presencia de lesiones genitales contribuye significativamente a las mayores tasas de desprendimiento en casos sintomáticos.
Área de la Ciencia:
- Virología Virología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Epidemiología La epidemiología.
Sus antecedentes:
- El diagnóstico del virus del herpes simplex genital tipo 2 (HSV-2) ha aumentado debido a las pruebas serológicas generalizadas.
- La historia natural del HSV-2 en individuos asintomáticos sigue sin estar clara.
Objetivo del estudio:
- Para comparar el curso virológico y clínico de la secreción genital del VHS en infecciones sintomáticas versus asintomáticas del VHS-2.
Principales métodos:
- Una cohorte de 498 individuos inmunocompetentes y seropositivos para el HSV-2 participaron en estudios prospectivos sobre el derramamiento genital del HSV.
- Los participantes recogieron diariamente por sí mismos hisopos genitales durante al menos 30 días.
- El ADN del VHS en los hisopos genitales se cuantificó utilizando la reacción en cadena de la polimerasa de fluorescencia en tiempo real.
Principales resultados:
- El HSV-2 se detectó en el 20,1% de los días en individuos sintomáticos frente al 10,2% en individuos asintomáticos (P < .001).
- Las tasas de eliminación subclínica fueron más altas en los individuos sintomáticos (13,1%) en comparación con los asintomáticos (8,8%) (P < .001).
- Las lesiones genitales representaron el 43.0% de los días de desprendimiento en casos sintomáticos, en comparación con el 16.4% en casos asintomáticos (P < .001).
Conclusiones:
- La infección asintomática por HSV-2 está asociada con un derramamiento viral genital menos frecuente en comparación con la infección sintomática.
- La diferencia en las tasas de desprendimiento se debe en gran medida a la presencia de lesiones genitales, que van acompañadas de una desprendimiento viral frecuente.
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