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Las nucleasas FEN: se unen, se doblan, se deshilachan, se cortan.

R Scott Williams¹, Thomas A Kunkel

¹Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, NC 27709, USA. williamsrs@niehs.nih.gov

|April 19, 2011

Resumen

Este resumen es generado por máquina.

Los investigadores descubrieron mecanismos moleculares clave detrás de las especificidades de la nucleasa RAD2/FEN. Estos hallazgos avanzan en nuestra comprensión de los procesos de replicación y mantenimiento del ADN.

Área de la Ciencia:

Biología Molecular Biología Molecular
La bioquímica es la bioquímica.
Genética La genética.

Sus antecedentes:

La superfamilia de nucleasas RAD2/FEN juega un papel crucial en la replicación y el mantenimiento del ADN.

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Comprender las especificidades de escisión de estas nucleasas es vital para comprender las vías de reparación del ADN.