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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...

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Video Experimental Relacionado

Updated: Jun 2, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Funciones sin sentido para ARN largos no codificantes.

Takashi Nagano1, Peter Fraser

  • 1Nuclear Dynamics and Function Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

Cell
|April 19, 2011
PubMed
Resumen
Este resumen es generado por máquina.

Los largos ARN no codificantes, la "materia oscura" del genoma, están revelando funciones complejas. Estudios recientes iluminan los diversos roles de estas moléculas enigmáticas en los procesos biológicos.

Videos de Experimentos Relacionados

Last Updated: Jun 2, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • La epigenética es la epigenética.

Sus antecedentes:

  • Los ARN largos no codificantes (ARNlnc) alguna vez fueron considerados ruido transcripcional.
  • Sus funciones reguladoras en la expresión génica y las funciones celulares son cada vez más reconocidas.
  • Los lncRNAs representan un componente significativo, aunque poco estudiado, del genoma eucariótico.

Objetivo del estudio:

  • Para dilucidar las funciones complejas y diversas de los ARN largos no codificantes.
  • Para resaltar los avances recientes en la comprensión de los mecanismos de lncRNA.
  • Para explorar la "materia oscura" del genoma.

Principales métodos:

  • Análisis bioinformáticos de secuencias de lncRNA y datos de expresión.
  • Estudios de genómica funcional, incluidos los experimentos de knockdown y sobreexpresión.
  • Tecnologías de secuenciación de alto rendimiento para identificar nuevos lncRNAs y sus objetivos.

Principales resultados:

  • Identificación de nuevos lncRNAs con funciones celulares específicas.
  • Caracterización de diversos mecanismos por los cuales los lncRNAs regulan la expresión génica.
  • Evidencia de la participación de los lncRNA en varias vías biológicas, incluido el desarrollo y la enfermedad.

Conclusiones:

  • Los ARN largos no codificantes poseen funciones multifacéticas más allá de la simple regulación génica.
  • Estas moléculas son jugadores críticos en los procesos celulares y la patogénesis de enfermedades.
  • Una mayor investigación sobre los lncRNAs promete importantes conocimientos sobre la función del genoma.