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Updated: Jun 2, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

Los elementos de respuesta negativa generalizados median la represión directa por el receptor de glucocorticoides

Milan Surjit1, Krishna Priya Ganti, Atish Mukherji

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR7104, Inserm U964, Université de Strasbourg, Collège de France, Illkirch, 67404, France.

Cell
|April 19, 2011
PubMed
Resumen

El receptor de glucocorticoides (GR) reprime directamente los genes al unirse a nuevas secuencias de ADN (IR nGREs), independientemente de los mecanismos previamente conocidos. Esta represión directa proporciona una nueva capa de regulación génica mediante la fluctuación de los niveles de glucocorticoides.

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