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Measurement of mRNA Decay Rates in Saccharomyces cerevisiae Using rpb1-1 Strains
Published on: December 13, 2014
SnapShot: La descomposición del ARNm mediada por tonterías.
Sébastien Durand1, Jens Lykke-Andersen
1Division of Biology, University of California San Diego, La Jolla, CA 92093, USA.
Cell
|April 19, 2011
Resumen
No abstract available in PubMed .
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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