Una vía de múltiples etapas para la agregación de proteínas priónicas humanas in vitro: desde semillas multiméricas

Kang R Cho1, Yu Huang, Shuiliang Yu

  • 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

Resumen

Se estudió la agregación proteica aberrante, un sello distintivo de la enfermedad de Creutzfeldt-Jakob (ECJ). Los investigadores descubrieron que los agregados de proteínas se forman a través de la asociación de pequeños β-oligómeros, no mediante la adición de proteínas individuales.

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