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pK(a) acoplamiento en el sitio activo de la inteína: implicaciones para el mecanismo de coordinación del empalme de

Zhenming Du1, Yuchuan Zheng, Melissa Patterson

  • 1Biology Department, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

Journal of the American Chemical Society
|May 25, 2011
PubMed
Resumen

Este estudio revela cómo un residuo específico de aspartato en la inteína Mtu RecA utiliza su alto pKa único para facilitar el empalme de proteínas. La protonación y desprotonación secuenciales de este aspartato coordinan los pasos iniciales de esta modificación crucial después de la traducción.

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