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Promiscuidad en la superfamilia de la fosfatasa alcalina. Desentrañar la evolución a través de simulaciones

Violeta López-Canut1, Maite Roca, Juan Bertrán

  • 1Departament de Química Física, Universitat de València, 46100 Burjassot, Spain.

Journal of the American Chemical Society
|May 26, 2011
PubMed
Resumen

La fosfatasa alcalina (AP) de Escherichia coli hidroliza los fosfodiésteros a través de un mecanismo disociativo conservado, similar a su actividad de monoesterasa. Las interacciones de las proteínas, particularmente con Lys328, dictan la especificidad y la promiscuidad del sustrato.

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