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Updated: Jun 1, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Los riesgos de cáncer asociados con mutaciones de la línea germinal en los genes MLH1, MSH2 y MSH6 en el síndrome de

Valérie Bonadona1, Bernard Bonaïti, Sylviane Olschwang

  • 1Université Lyon 1, Centre National de la Recherche Scientifique UMR5558, Villeurbanne, Centre Léon Bérard, Lyon, Cedex 08, France.

JAMA
|June 7, 2011
PubMed
Resumen

Los riesgos de cáncer del síndrome de Lynch varían significativamente según la mutación genética. Las mutaciones MSH6 conllevan menores riesgos, mientras que las mutaciones MLH1 y MSH2 presentan mayores riesgos, especialmente después de los 40 años.

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