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Los cambios dinámicos en las células T reguladoras están relacionados con los niveles de hipercolesterolemia inducida
Elena Maganto-García1, Margarite L Tarrio, Nir Grabie
1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 7, Boston, MA 02115, USA.
Circulation
|June 22, 2011
Resumen
El colesterol alto prolongado deteriora las células T reguladoras (Treg) en las lesiones ateroscleróticas. Invertir el colesterol alto puede preservar Treg, lo que sugiere que las terapias para reducir el colesterol pueden mejorar el equilibrio de Treg en la aterosclerosis.
Área de la Ciencia:
- Inmunología Inmunología.
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- La patogénesis y la patogénesis de la aterosclerosis.
Sus antecedentes:
- Las células T reguladoras (Treg) se infiltran en las lesiones ateroscleróticas e influyen en la progresión de la enfermedad.
- Comprender la dinámica de los Treg durante la hipercolesterolemia es crucial para las estrategias terapéuticas.
Objetivo del estudio:
- Para investigar los cambios en las respuestas de Treg durante la hipercolesterolemia prolongada y la progresión de la aterosclerosis.
- Evaluar el impacto de la reversión de la hipercolesterolemia en las poblaciones de Treg dentro de las lesiones.
Principales métodos:
- Utilizado receptor nulo de lipoproteína de baja densidad en ratones alimentados con control o dietas ricas en colesterol.
- Células Treg positivas para proteínas fluorescentes verdes cuantificadas en tejidos linfoides y aorta.
- Evaluación de la función Treg, la apoptosis y las proporciones de células T en respuesta a las intervenciones dietéticas.
Principales resultados:
- Los números de Treg esplénico aumentaron con la dieta prolongada de colesterol, pero el Treg lesional disminuyó después de 4 semanas.
- La hipercolesterolemia redujo la unión de Treg al endotelio y aumentó la apoptosis de Treg.
- La reversión de la dieta después de 4 semanas mantuvo el Treg lesional y detuvo el crecimiento de la lesión.
Conclusiones:
- La hipercolesterolemia prolongada tiene un impacto negativo en la acumulación de Treg en las lesiones ateroscleróticas.
- La reversión de la hipercolesterolemia puede prevenir la pérdida de Treg y potencialmente restaurar las relaciones de células T efectoras de Treg beneficiosas.
- Las terapias para reducir el colesterol pueden ofrecer una estrategia para modular las respuestas de Treg en la aterosclerosis.
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