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Videos de Conceptos Relacionados

Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Transformation of Plane Strain01:12

Transformation of Plane Strain

When analyzing elongated structures like bars subjected to uniformly distributed loads, it is essential to understand the transformation of plane strain when coordinate axes are rotated. This transformation helps to assess how material deformation characteristics vary with orientation, which is crucial in materials science and structural engineering.
Under plane strain conditions, typical for members where one dimension significantly exceeds the others, deformations and resultant strains are...
Surface Tension01:24

Surface Tension

Surface tension is defined as the force per unit length (γ) acting along the surface of a liquid. It arises due to strong intermolecular forces of attraction. A molecule located inside the bulk of the liquid is surrounded by other molecules and experiences equal forces in all directions. However, a molecule at the surface experiences unbalanced forces because there are more neighboring molecules below than above. This creates a net inward force that pulls surface molecules toward the interior,...
Deformations in a Transverse Cross Section01:21

Deformations in a Transverse Cross Section

When a material is subjected to uniaxial stress, it elongates or contracts in the direction of the applied force, and also undergoes changes in the perpendicular directions. This behavior is crucial for understanding how materials behave under stress and is governed by mechanical properties such as Poisson's ratio v, which measures the ratio of transverse strain to axial strain.
As the material stretches, it expands or contracts in orthogonal directions to the load. This phenomenon varies...
Temperature Dependent Deformation01:12

Temperature Dependent Deformation

In a nonhomogeneous rod made up of steel and brass, restrained at both ends and subjected to a temperature change, several steps are involved in calculating the stress and compressive load. Due to the problem's static indeterminacy, one end support is disconnected, allowing the rod to experience the temperature change freely. Next, an unknown force is applied at the free end, triggering deformations in the rod's steel and brass portions. These deformations are then calculated and added together...
Bending of Curved Members - Neutral Surface01:16

Bending of Curved Members - Neutral Surface

In curved beams, unlike straight beams, the stress distribution across the cross-section is not uniform due to the beam's curvature. This non-uniformity arises because the neutral axis, where stress is zero, does not align with the centroid of the section. In a curved beam, the strain varies along the section as a function of the distance from the neutral axis.
Consider the curved member described in the previous lesson. According to Hooke's law, which relates stress to strain within the...

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Updated: May 31, 2026

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

Control de la transformación de los tejidos en superficies de gradiente dinámico.

Wei Luo1, Muhammad N Yousaf

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Journal of the American Chemical Society
|June 29, 2011
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores crearon superficies inteligentes para controlar el comportamiento de las células de mamíferos a través del tiempo y el espacio. Estas superficies dinámicas guían la adhesión celular, la configuración del tejido y la migración para estudios biológicos avanzados.

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Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
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Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

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Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
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Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Área de la Ciencia:

  • Ciencia de los Biomateriales Ciencia de los Biomateriales.
  • Biología celular Biología celular.
  • La ingeniería de tejidos es la ingeniería de tejidos.

Sus antecedentes:

  • El control del comportamiento celular de los mamíferos es crucial para la ingeniería tisular y la medicina regenerativa.
  • Los métodos existentes a menudo carecen de precisión espacial y temporal para guiar las actividades celulares.

Objetivo del estudio:

  • Desarrollar nuevas superficies inteligentes que permitan un control espacial y temporal preciso sobre el comportamiento de las células de los mamíferos.
  • Investigar el uso de gradientes dinámicos de la superficie de los ligandos para la adhesión celular, la morfología de los tejidos y la migración.

Principales métodos:

  • Integración de una estrategia de superficie bioactiva con una estrategia de superficie fotoelectroactiva.
  • Generación de gradientes dinámicos de la superficie del ligando.
  • Utilizando estos gradientes para influir en la adhesión celular de mamíferos, la forma del tejido y los patrones de migración.

Principales resultados:

  • Demostró un control espacial y temporal exitoso del comportamiento celular de los mamíferos.
  • Demostró la capacidad de los gradientes de ligando dinámicos para modular la adhesión celular y la morfología tisular.
  • Migración controlada de células y tejidos en respuesta a estímulos superficiales.

Conclusiones:

  • Las superficies inteligentes ofrecen una poderosa plataforma para el control preciso de la dinámica celular y tisular.
  • La integración de superficies fotoelectroactivas y bioactivas desarrollada proporciona una herramienta versátil para la investigación basada en células.
  • Este enfoque tiene implicaciones significativas para el avance de la ingeniería tisular y la comprensión de la biología del desarrollo.