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Updated: May 30, 2026

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
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Acompañantes moleculares en el plegamiento de proteínas y la proteostasis

F Ulrich Hartl1, Andreas Bracher, Manajit Hayer-Hartl

  • 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. uhartl@biochem.mpg.de

Nature
|July 22, 2011
PubMed
Resumen

Las células utilizan chaperones moleculares para garantizar el plegamiento adecuado de las proteínas y prevenir la agregación tóxica, manteniendo la homeostasis de las proteínas (proteostasis). La disminución de la proteostasis con la edad está relacionada con enfermedades neurodegenerativas como el Alzheimer y el Parkinson.

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