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Experience-Dependent Remodeling of Juvenile Brain Olfactory Sensory Neuron Synaptic Connectivity in an Early-Life Critical Period
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La poda sináptica por microglia es necesaria para el desarrollo normal del cerebro

Rosa C Paolicelli1, Giulia Bolasco, Francesca Pagani

  • 1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Via Ramarini 32, 00015 Monterotondo, Italy.

Science (New York, N.Y.)
|July 23, 2011
PubMed
Resumen

La microglia, las células inmunes del cerebro, recortan activamente las sinapsis durante el desarrollo. Esta función esencial en la maduración sináptica puede verse afectada en trastornos del desarrollo neurológico.

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