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Updated: May 30, 2026
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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
La trifluorometoxilación mediada por plata de los estananos de arilo y los ácidos arilborónicos
Chenghong Huang1, Theresa Liang, Shinji Harada
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Journal of the American Chemical Society
|August 11, 2011
Resumen
Una nueva reacción catalizada por plata crea éteres de arilo trifluorometilo a partir de estananos de arilo y ácidos borónicos. Este es el primer método catalizado por metales de transición para la formación del enlace C ((arylo) -OCF ((3)).
Área de la Ciencia:
- Química orgánica es la química orgánica.
- Química organometálica Química orgánica de los metales.
Sus antecedentes:
- Los éteres de trifluorometilo de arilo son importantes motivos estructurales en los productos farmacéuticos y la ciencia de los materiales.
- Los métodos directos para sintetizar el enlace C ((arylo) -OCF ((3) siguen siendo un reto.
Objetivo del estudio:
- Desarrollar un nuevo método catalizado por metales de transición para la síntesis de éteres de arilo trifluorometilo.
- Para establecer una nueva ruta para la formación de enlaces C(arilo) -OCF(3).
Principales métodos:
- Reacción de acoplamiento cruzado mediada por plata.
- Utilizó estananos de arilo y ácidos arilborónicos como socios de acoplamiento.
- Se utiliza el trifluorometóxido como agente trifluorometoxilador.
Principales resultados:
- Se han sintetizado con éxito éteres de arilo trifluorometil.
- Demostró la primera formación de enlaces catalizados por metales de transición C(arilo) -OCF(3).
- La reacción procede a través de una vía mediada por plata.
Conclusiones:
- Desarrolló un eficiente acoplamiento cruzado catalizado por plata para la síntesis de éter de arilo trifluorometil.
- Este trabajo proporciona una nueva estrategia sintética para acceder a valiosos compuestos organofluorados.
- La metodología ofrece un nuevo enfoque para la construcción de enlaces C(arilo) -OCF(3).
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