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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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Polímerosomas múltiples para la liberación programada de múltiples componentes.

Shin-Hyun Kim1, Ho Cheung Shum, Jin Woong Kim

  • 1School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, Massachusetts, United States.

Journal of the American Chemical Society
|August 16, 2011
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron un método microfluídico para crear polimerosomas en polimerosomas para la liberación controlada de múltiples componentes. Este nuevo sistema de administración ofrece una alta eficiencia de encapsulación y programabilidad para aplicaciones farmacéuticas y cosméticas.

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Área de la Ciencia:

  • Ciencia de los Biomateriales Ciencia de los Biomateriales.
  • Nanotecnología La nanotecnología es la nanotecnología.
  • Ingeniería Química Ingeniería Química.

Sus antecedentes:

  • Los polimerosomas son prometedores vehículos de administración de fármacos, pero luchan con la coencapsulación y la liberación controlada de múltiples componentes.
  • Los métodos actuales carecen de la capacidad de administrar de forma independiente múltiples cargas útiles dentro de un solo sistema de entrega, lo que limita las aplicaciones en productos farmacéuticos y cosméticos.

Objetivo del estudio:

  • Desarrollar un enfoque microfluídico para la creación de polimerosomas multicapa capaces de encapsular y liberar secuencialmente múltiples componentes.
  • Permitir el almacenamiento controlado y a largo plazo y la liberación de diversas sustancias sin contaminación cruzada.

Principales métodos:

  • Se empleó una técnica microfluídica para generar gotas de emulsión doble monodispersa, que sirven como plantillas para polimerosomas multicapa.
  • La inyección secuencial de las fases de emulsión permitió la creación de estructuras de "polimerosomas en polimerosomas".
  • La incorporación de homopolímeros hidrofóbicos en las bicapas facilitó la disociación secuencial programada de la membrana.

Principales resultados:

  • Se ha producido con éxito "polímerosomas-en-polímerosomas" multicapa con alta eficiencia de encapsulación.
  • Liberación programada y secuencial demostrada de componentes encapsulados a través de la disociación controlada de dos capas.
  • El método microfluídico permite la creación de estructuras polimerosas complejas de orden superior.

Conclusiones:

  • El enfoque microfluídico desarrollado permite la creación de sistemas avanzados de polímerosomas para la entrega de múltiples componentes.
  • Esta tecnología ofrece capacidades programables de liberación secuencial, superando las limitaciones de los vehículos polimerómicos existentes.
  • La biocompatibilidad y la eficiencia de este método presentan nuevas vías para sistemas de entrega sofisticados en varias industrias.