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Updated: May 30, 2026

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Published on: May 30, 2021

La α-Synuclein ocurre fisiológicamente como un tetramero plegado helicoidal que resiste la agregación

Tim Bartels1, Joanna G Choi, Dennis J Selkoe

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 16, 2011
PubMed
Resumen

La enfermedad de Parkinson involucra alfa-sinucleína mal plegada (α-sinucleína). Este estudio revela que la α-sinucleína endógena forma un tetrámero estable, no un monómero, lo que sugiere que la estabilización del tetrámero puede prevenir la patología de la enfermedad de Parkinson.

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