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Un nuevo escudo para una tormenta de citoquinas

Akiko Iwasaki¹, Ruslan Medzhitov

¹Department of Immunobiology, School of Medicine, Yale University New Haven, CT 06520, USA.

|September 20, 2011

Resumen

Los ligandos del receptor 1 de esfingosina-1-fosfato pueden suprimir la inflamación patológica causada por infecciones graves por el virus de la gripe. Esta investigación pone de relieve el endotelio.

Área de la Ciencia:

Inmunología Inmunología.
Virología Virología.
Biología Molecular Biología Molecular

Sus antecedentes:

Las infecciones graves por el virus de la gripe desencadenan una liberación excesiva de citoquinas, infiltración de leucocitos y lesión pulmonar.
Comprender los mecanismos del daño pulmonar inmunomediado durante la gripe es crucial.

Objetivo del estudio:

Para investigar el papel de los ligandos del receptor de esfingosina-1-fosfato 1 (S1PR1) en la regulación de la inflamación inducida por la gripe.
Determinar si los ligandos S1PR1 pueden mitigar las consecuencias patológicas de las infecciones virulentas por gripe.

Principales métodos:

Utilizó un modelo de ratón de infección por el virus de la gripe altamente virulenta.
Ligandos S1PR1 administrados a animales infectados.
Se evaluaron los marcadores inflamatorios, el reclutamiento de células inmunes y la lesión pulmonar.

Principales resultados:

Los ligandos S1PR1 suprimieron efectivamente la producción excesiva de citoquinas.
El tratamiento con ligandos redujo el reclutamiento de leucocitos en los pulmones.
La inflamación y lesión pulmonar patológica mejoraron significativamente.
El endotelio fue identificado como un componente central en esta red reguladora.

Conclusiones:

Los ligandos de S1PR1 ofrecen una estrategia terapéutica potencial para el manejo de la gripe grave.
Dirigirse a la señalización S1PR1 en el endotelio puede controlar la inmunopatología inducida por la gripe.

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