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Updated: May 22, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Transferencia enzimática de metilo: papel de un residuo del sitio activo en la generación de la compactación del

Jianyu Zhang1, Judith P Klinman

  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.

Journal of the American Chemical Society
|October 1, 2011
PubMed
Resumen

La actividad de la enzima humana catecol-O-metiltransferasa (COMT) está relacionada con la compactación del sitio activo. Las mutaciones revelan una correlación entre la eficiencia catalítica y los efectos cinéticos de los isótopos, que afectan el metabolismo de la dopamina.

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