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Control bidireccional de la jerarquía social por la eficacia sináptica en la corteza prefrontal medial
1Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Science (New York, N.Y.)
|October 1, 2011
Resumen
El rango social en ratones está determinado por la fuerza sináptica en la corteza prefrontal medial (mPFC). La alteración de este circuito neuronal puede cambiar la posición social de un animal, revelando plasticidad en las jerarquías de dominación.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Comportamiento animal Comportamiento animal.
- La jerarquía social La jerarquía social.
Sus antecedentes:
- Las jerarquías de dominio influyen significativamente en la supervivencia, la salud y la reproducción de los animales.
- Los mecanismos neuronales que subyacen a la determinación del rango social siguen siendo en gran medida inexplorados.
Objetivo del estudio:
- Para investigar los mecanismos de circuito neuronal de la jerarquía social en ratones.
- Para determinar el papel de la corteza prefrontal medial (mPFC) en el rango social.
Principales métodos:
- Se evaluó la estabilidad y la transitividad del rango de dominación en ratones.
- La fuerza de entrada sináptica registrada en las neuronas piramidal de la capa V de la corteza prefrontal medial (mPFC).
- Eficacia sináptica manipulada en las neuronas mPFC y efectos observados en el rango social.
Principales resultados:
- Se encontró que la clasificación de dominio en ratones era estable y transitiva.
- Los ratones de mayor rango exhibieron entradas sinápticas excitatorias más fuertes en las neuronas mPFC en comparación con los subordinados.
- El aumento de la eficacia sináptica en las neuronas mPFC condujo a un rango social más alto, mientras que la disminución de la eficacia condujo a un rango más bajo.
Conclusiones:
- La corteza prefrontal medial (mPFC) juega un papel crucial en el establecimiento y mantenimiento de la jerarquía social.
- El rango social es un rasgo plástico que puede ser modulado mediante la alteración de la fuerza sináptica en las neuronas piramidal mPFC.
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