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Updated: May 5, 2026

Recombinant Retroviral Production and Infection of B Cells

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El mapeo de la translocación expone el estilo de vida arriesgado de las células B

Rachel Patton McCord¹, Job Dekker

¹Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-0103, USA.

|October 4, 2011

Resumen

Las translocaciones cromosómicas recurrentes conducen al cáncer, pero su formación no está clara. Los estudios revelan que las ubicaciones específicas del ADN son propensas a los reordenamientos después de una sola ruptura de doble cadena, arrojando luz sobre la oncogénesis.

Área de la Ciencia:

Genética La genética.
Biología del cáncer Biología del cáncer.
La genómica es la genómica.

Sus antecedentes:

Las translocaciones cromosómicas recurrentes son características de muchos tipos de cáncer, impulsando la oncogénesis.
Los mecanismos precisos que subyacen a la formación de estas translocaciones, particularmente de una sola ruptura de ADN, siguen siendo en gran medida desconocidos.

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