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La asociación de la actividad física con la función endotelial vascular y el grosor de la íntima-media
Katja Pahkala1, Olli J Heinonen, Olli Simell
1University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, FI-20520 Turku, Finland. katja.pahkala@utu.fi
Circulation
|October 5, 2011
Resumen
La actividad física regular en adolescentes mejora la salud vascular, mejora la función endotelial y reduce el espesor íntima-medio (IMT). Incluso un aumento moderado de la actividad puede retrasar significativamente la progresión de los marcadores de la aterosclerosis.
Área de la Ciencia:
- Salud Cardiovascular La salud cardiovascular.
- Medicina de la Adolescencia y la Adolescencia
- Cardiología Preventiva y Cardiología Preventiva.
Sus antecedentes:
- La aterogénesis comienza con la disfunción endotelial y el aumento del grosor de la íntima-media (IMT).
- Los datos longitudinales sobre el impacto de la actividad física en la salud vascular de los adolescentes son limitados.
Objetivo del estudio:
- Investigar prospectivamente la asociación entre la actividad física en el tiempo libre y la función endotelial (dilatación mediada por flujo; FMD) y la TMI aórtica en adolescentes sanos.
Principales métodos:
- Un estudio longitudinal siguió a 553 adolescentes de 13 a 17 años de edad.
- Los parámetros vasculares (FMD, IMT) se midieron a través de la ecografía.
- La actividad física en el tiempo de ocio se cuantificó utilizando el equivalente metabólico (MET) de horas por semana.
Principales resultados:
- La actividad física mostró una asociación directa con la función endotelial (máxima FMD, respuesta total a la FMD) y una asociación inversa con IMT.
- Los adolescentes que aumentaron la actividad física demostraron una mejoría en la fiebre aftosa y una reducción en la progresión de la IMT en comparación con los compañeros sedentarios.
- Los adolescentes persistentemente activos habían atenuado la progresión de la IMT en comparación con aquellos que se volvían sedentarios.
Conclusiones:
- La actividad física está favorablemente relacionada con la función endotelial y la TMI en adolescentes.
- Los aumentos moderados en la actividad física reducen la progresión de la IMT.
- Un estilo de vida activo puede prevenir cambios ateroscleróticos subclínicos en los adolescentes.
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