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Dinámica de las estrategias de recuperación de memorias remotas
Inbal Goshen1, Matthew Brodsky, Rohit Prakash
1Department of Bioengineering, Howard Hughes Medical Institute, CNC Program, Stanford University, Stanford, CA 94305, USA.
Cell
|October 25, 2011
Resumen
La recuperación de la memoria a largo plazo típicamente involucra al hipocampo, pero este estudio muestra que puede adaptarse. La inhibición temporal de las neuronas CA1 del hipocampo abolió de forma reversible los recuerdos remotos de miedo, revelando la plasticidad de la memoria.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación de la memoria Investigación de la memoria.
- La neurociencia de sistemas es la neurociencia de sistemas.
Sus antecedentes:
- Se cree que la memoria a largo plazo implica el procesamiento secuencial del hipocampo y el neocórtex.
- Las memorias remotas generalmente se consideran independientes del hipocampo.
- Estudios previos sugieren que los recuerdos de miedo contextual se vuelven independientes del hipocampo con el tiempo.
Objetivo del estudio:
- Investigar la contribución en tiempo real de las neuronas excitatorias CA1 del hipocampo al recuerdo remoto de la memoria.
- Para examinar la plasticidad de los mecanismos de recuperación de la memoria.
- Para explorar el papel de la corteza cingulada anterior (ACC) en la memoria remota.
Principales métodos:
- Utilizó técnicas optogenéticas rápidas para una manipulación precisa y en tiempo real de la actividad neuronal.
- Examinó los efectos de la inhibición optogenética temporalmente específica de las neuronas CA1 del hipocampo en el recuerdo remoto de la memoria del miedo contextual en roedores.
- Investigó el papel de la corteza cingulada anterior (ACC) en el recuerdo remoto de la memoria.
Principales resultados:
- La abolición reversible de la memoria de miedo contextual remota se logró mediante la inhibición optogenética de las neuronas CA1 del hipocampo, incluso semanas después del entrenamiento.
- La inhibición extendida que imita las líneas de tiempo farmacológicas cambió la recuperación de la memoria remota de dependiente del hipocampo a independiente.
- Confirmó la importancia de la corteza cingulada anterior (ACC) para la memoria remota y implicó el CA1 hipocampal en el reclutamiento de ACC.
Conclusiones:
- La recuperación de la memoria remota no es estrictamente independiente del hipocampo y puede ser modulada de manera reversible por la actividad CA1 del hipocampo.
- Los mecanismos de recuperación de la memoria exhiben plasticidad, lo que permite cambios adaptativos en los sustratos neuronales.
- El hipocampo (CA1) juega un papel en el reclutamiento de otras regiones cerebrales, como el ACC, para el recuerdo remoto de la memoria.
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