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Los ligandos naturales del receptor de hidrocarburos de arilo controlan la organogénesis de los folículos linfoides
Elina A Kiss1, Cedric Vonarbourg, Stefanie Kopfmann
1Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany.
Science (New York, N.Y.)
|October 29, 2011
Resumen
Los nutrientes dietéticos, como los de las verduras Brassicaceae, activan el receptor de hidrocarburos de arilo (AhR) en las células linfoides innatas (ILC). Esta señalización AhR es crucial para la formación de folículos linfoides intestinales y el mantenimiento de la inmunidad intestinal contra las infecciones.
Área de la Ciencia:
- Inmunología Inmunología.
- Microbiología Microbiología.
- Ciencia de la nutrición Ciencia de la nutrición.
Sus antecedentes:
- Las células linfoides innatas (CLI) que expresan RORγt son vitales para la homeostasis intestinal y la formación de folículos linfoides.
- El receptor de hidrocarburos de arilo (AhR) es un factor de transcripción conservado involucrado en la adaptación a los desafíos ambientales.
Objetivo del estudio:
- Investigar el papel de AhR en el desarrollo y la función de RORγt ((+) ILC.
- Para determinar si los componentes de la dieta pueden modular la actividad AhR en ILC e influir en la inmunidad intestinal.
Principales métodos:
- Se utilizaron modelos de ratones con deficiencia de AhR.
- Estudió el impacto de los ligandos dietéticos, específicamente de las verduras Brassicaceae.
- Evaluación de la susceptibilidad a la infección por Citrobacter rodentium.
Principales resultados:
- AhR es esencial para la expansión postnatal de RORγt(+) ILC y el desarrollo del folículo linfoide intestinal.
- Los ligandos dietéticos, como los de las verduras Brassicaceae, pueden inducir la actividad AhR en RORγt ((+) ILC.
- Los ratones con deficiencia de AhR mostraron una mayor susceptibilidad a la infección por Citrobacter rodentium.
Conclusiones:
- Establece un vínculo molecular entre los nutrientes de la dieta y el desarrollo del sistema inmunológico intestinal.
- Destaca el papel crítico de la señalización AhR en RORγt ((+) ILC para mantener la homeostasis intestinal y la resistencia a las infecciones.
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