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Updated: May 27, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Published on: January 16, 2016

Evaluación de la contribución catalítica del agujero de oxyanión en la isomerasa cetosteroide

Jason P Schwans1, Fanny Sunden, Ana Gonzalez

  • 1Department of Biochemistry, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|November 8, 2011
PubMed
Resumen

La alteración del agujero de oxyanión en la isomerasa cetosteroide (KSI) revela su papel catalítico. Las mutaciones que imitan las interacciones de la solución acuosa mostraron una menor reducción de la tasa, lo que indica contribuciones de enlaces de hidrógeno dependientes del contexto.

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