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Las células de la red utilizan los canales HCN1 para el escalamiento espacial

Lisa M Giocomo¹, Syed A Hussaini, Fan Zheng

¹Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7030 Trondheim, Norway. lisa.m.giocomo@ntnu.no

|November 22, 2011

Resumen

La corriente catiónica activada por la hiperpolarización (Ih) influye en la navegación espacial. El bloqueo de los canales HCN1 expandió el espaciamiento de las células de la red, lo que sugiere que Ih es crucial para transformar el movimiento en campos de disparo espaciales.

Área de la Ciencia:

La neurociencia es la neurociencia.
La neurociencia computacional es la neurociencia computacional.
La neurociencia celular es la neurociencia celular.

Sus antecedentes:

Las células de la rejilla entorrinal exhiben patrones de disparo hexagonales que se escalan a lo largo del eje dorsal-ventral de la corteza entorrinal medial.
Este escalamiento se correlaciona con las propiedades celulares influenciadas por la corriente catiónica activada por hiperpolarización (Ih), mediada por canales activados por hiperpolarización de nucleótidos cíclicos (HCN).

Objetivo del estudio:

Investigar el papel de Ih en la determinación de la escala de disparo de las células de la red.
Para probar la hipótesis de que Ih tiene un impacto directo en la escala de la red.

Principales métodos:

Nocaut específico del cerebro anterior de HCN1 en ratones.
Registro de la actividad de las células de la red y la modulación theta.
Análisis del tamaño del campo de la cuadrícula, el espaciado y la periodicidad de la modulación theta.

Principales resultados:

El gradiente dorsal-ventral de los patrones de cuadrícula se mantuvo en los ratones knockout HCN1.
El tamaño del campo de la cuadrícula, el espaciado y el período de modulación theta se ampliaron en todos los niveles.
La modulación theta de las interneuronas entorrinal se mantuvo sin cambios.

Conclusiones:

La corriente catiónica activada por hiperpolarización (Ih) es un determinante clave de la escala de la red.
Ih puede contribuir a la transformación de señales de auto-movimiento en campos de disparo espaciales para la navegación.

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