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Un archipiélago regulador controla la transcripción de los genes Hox en dígitos
Thomas Montavon1, Natalia Soshnikova, Bénédicte Mascrez
1National Research Centre, Frontiers in Genetics, School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.
Cell
|November 29, 2011
Resumen
La regulación del gen Hoxd en el desarrollo de los dígitos implica un "archipiélago regulador" de potenciadores. Este sistema permite la flexibilidad, explicando potencialmente la diversidad y la resiliencia de los dígitos tetrápodos.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Biología evolutiva Biología evolutiva.
- Genética La genética.
Sus antecedentes:
- El éxito de los tetrápodos está vinculado a la evolución de los dígitos.
- Los genes Hoxd son cruciales para el desarrollo del dígito, organizando el crecimiento y los patrones.
- Comprender la regulación del gen Hoxd es clave para entender la evolución del dígito.
Objetivo del estudio:
- Para identificar los sitios reguladores distales que controlan los genes Hoxd en los dígitos en desarrollo.
- Para investigar la arquitectura tridimensional de la unidad reguladora del gen Hoxd.
- Para aclarar la contribución funcional de los elementos reguladores a la transcripción del gen Hox.
Principales métodos:
- Probando la arquitectura 3D de la unidad reguladora del gen Hoxd en el desarrollo de las extremidades.
- Eliminaciones in vivo de distintas regiones reguladoras.
- Análisis de secuencias similares a potenciadores dispersos en el desierto de genes.
Principales resultados:
- Identificación de sitios reguladores distales que interactúan con el grupo de genes Hoxd activo.
- Estos elementos similares a potenciadores se encuentran en el desierto de genes.
- Cada elemento contribuye cuantitativa o cualitativamente a la transcripción del gen Hox en dígitos.
Conclusiones:
- Propuso un nuevo sistema genético denominado "archipiélago regulador" para la regulación del gen Hoxd.
- Este sistema ofrece una flexibilidad inherente en la regulación génica.
- El "archipiélago regulatorio" puede explicar la diversidad y la resiliencia de los dedos de los tetrápodos.
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