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Videos de Conceptos Relacionados

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Adhesión celular químicamente programada con oligonucleótidos anclados en la membrana.

Nicholas S Selden1, Michael E Todhunter, Noel Y Jee

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street Box 2280, San Francisco, California 94158, USA.

Journal of the American Chemical Society
|December 20, 2011
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron un nuevo método químico para controlar la adhesión celular utilizando el ADN. Esta técnica permite una unión celular rápida y sintonizable independiente de las proteínas, lo que permite nuevas formas de estudiar el comportamiento celular y los efectos de los medicamentos.

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Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Biología Molecular Biología Molecular
  • Ciencia de los materiales Ciencia de los materiales.

Sus antecedentes:

  • La adhesión celular es crucial para la organización e integración de los tejidos.
  • Los métodos actuales a menudo se basan en proteínas o glicanos, lo que limita el control e introduce complejidad.
  • Existe la necesidad de un control preciso y químico sobre la adhesión celular.

Objetivo del estudio:

  • Desarrollar una estrategia química para controlar la adhesión celular utilizando oligonucleótidos de ADN.
  • Para permitir las interacciones celulares independientes de las proteínas y los glicanos.
  • Para demostrar la utilidad de este método para el estudio de la dinámica de la membrana celular.

Principales métodos:

  • Oligonucleótidos de ADN de una sola hebra anclados en la membrana sintetizados a partir de fosforamiditas.
  • Utilizó interacciones complementarias entre hebras de ADN en células y superficies.
  • Células humanas químicamente inmovilizadas y no adheridas en superficies de vidrio pasivado.

Principales resultados:

  • Se logró una adhesión celular rápida, eficiente y ajustable utilizando la estrategia basada en el ADN.
  • Adhesión celular demostrada independiente de las proteínas naturales de la superficie celular o de los glicanos.
  • Se obtuvieron con éxito imágenes de los cambios inducidos por fármacos en la dinámica de la membrana de las células inmovilizadas.

Conclusiones:

  • Los oligonucleótidos de ADN anclados en la membrana ofrecen un enfoque químico versátil para controlar la adhesión celular.
  • Este método proporciona una poderosa herramienta para la inmovilización celular y el estudio de los procesos celulares dinámicos.
  • La naturaleza química de los reactivos permite una síntesis sencilla y una amplia aplicabilidad.