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Cambios temporales en la frecuencia cardíaca en reposo y muertes por enfermedad isquémica del corazón
Javaid Nauman1, Imre Janszky, Lars J Vatten
1K. G. Jebsen Center of Exercise in Medicine, PO Box 8905, Medisinsk Teknisk Forskningssenter, 7491 Trondheim, Norway.
JAMA
|December 22, 2011
Resumen
Un aumento de la frecuencia cardíaca en reposo (RHR) durante diez años está relacionado con un mayor riesgo de muerte por enfermedad isquémica del corazón (IHD). Este estudio destaca la importancia de monitorear los cambios de RHR para la salud cardiovascular.
Área de la Ciencia:
- Cardiología Cardiología.
- Epidemiología La epidemiología.
- Salud Pública La salud pública.
Sus antecedentes:
- La frecuencia cardíaca en reposo (RHR) es un predictor conocido del riesgo cardiovascular.
- El impacto de los cambios de RHR temporal en la mortalidad por enfermedad isquémica del corazón (IHD) en la población general sigue sin estar claro.
Objetivo del estudio:
- Investigar la asociación entre los cambios longitudinales a largo plazo en la RHR y el riesgo de muerte por DHI.
- Para evaluar la relación entre las fluctuaciones de RHR y la mortalidad por cualquier causa.
Principales métodos:
- Estudio de cohorte prospectivo de 29.325 individuos en Noruega, con RHR medido dos veces, aproximadamente con 10 años de diferencia.
- Los análisis de regresión de Cox se utilizaron para estimar los ratios de riesgo para la EII y la mortalidad por cualquier causa en función de los cambios en la HRR.
- El seguimiento de la mortalidad se llevó a cabo hasta el 31 de diciembre de 2008.
Principales resultados:
- Un aumento en la RHR durante el período de 10 años se asoció con un riesgo significativamente mayor de muerte por DHI.
- Los participantes cuya RHR aumentó de <70 a >85 latidos/min tuvieron un aumento de 1,9 veces el riesgo de muerte por EII.
- La asociación entre el cambio de RHR y la mortalidad por EII no fue lineal, y no se observó ningún beneficio de mortalidad por la disminución de RHR.
Conclusiones:
- En individuos sin enfermedad cardiovascular previa, un aumento de la RHR durante una década se asocia con un mayor riesgo de mortalidad por EII.
- El aumento de la RHR con el tiempo también se correlacionó con un aumento de la mortalidad por todas las causas, aunque en menor medida que la mortalidad por EII.
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