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Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
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Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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La neurociencia. la neurociencia. Diferenciación de la barrera hematoencefálica diferenciación de la barrera

Britta Engelhardt1

  • 1Theodor Kocher Institute, University of Bern, Bern, Switzerland. bengel@tld.unibe.ch

Science (New York, N.Y.)
|December 24, 2011
PubMed
Resumen

No abstract available in PubMed .

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...