Video Experimental Relacionado
Updated: May 26, 2026
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Enfermedad estreptocócica del grupo B en lactantes menores de 3 meses: revisión sistemática y metanálisis
Karen M Edmond1, Christina Kortsalioudaki, Susana Scott
1London School of Hygiene and Tropical Medicine, London, UK. karen.edmond@lshtm.ac.uk
Lancet (London, England)
|January 10, 2012
Resumen
El estreptococo del grupo B (GBS) causa enfermedades y muertes infantiles significativas en todo el mundo. Una vacuna dirigida a cinco serotipos de GBS podría prevenir la mayoría de los casos de enfermedad invasiva de GBS.
Área de la Ciencia:
- Salud Global La salud global.
- Enfermedades infecciosas Enfermedades infecciosas.
- La pediatría es la medicina de los niños.
Sus antecedentes:
- El estreptococo del grupo B (GBS) es una de las principales causas de morbilidad y mortalidad infantil en todo el mundo.
- La profilaxis antibiótica intraparto es ampliamente utilizada, pero las estimaciones de la carga de la enfermedad por GBS faltan para muchas regiones.
Objetivo del estudio:
- Para examinar la carga global actual de la enfermedad GBS invasiva.
- Para determinar la distribución del serotipo de los aislados de GBS.
Principales métodos:
- Buscó en las bases de datos Medline, Embase y Wholis para estudios sobre la enfermedad invasiva del SGB (inicio temprano y final).
- Se incluyen estudios que informan la incidencia, las muertes o los serotipos; se revisan las listas de referencia y se pone en contacto con expertos para obtener datos no publicados.
- Utilizó un metanálisis de efectos aleatorios para agrupar datos de 74 estudios elegibles.
Principales resultados:
- La incidencia media de GBS en bebés (0-89 días) fue de 0,53 por cada 1000 nacidos vivos, con una tasa de mortalidad del 9,6%.
- La incidencia y la fatalidad de GBS de aparición temprana fueron el doble que la de la enfermedad de aparición tardía.
- El serotipo III fue el más común (48,9%), seguido de Ia (22,9%), V (9,1%), Ib (7,0%) y II (6,2%).
Conclusiones:
- Se necesitan más estudios de alta calidad, especialmente en países de bajos ingresos, para estimar con precisión la carga del GBS.
- Una vacuna conjugada dirigida a los serotipos Ia, Ib, II, III y V podría prevenir la mayoría de las enfermedades globales por SGB.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:26Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
01:21Rheumatic Heart Disease III: Medical Management
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...